![]() However, until the investigation in to your account is competed no apps under your account will be reviewed. I understand that you do not agree with the way the investigation is being carried out. I am tried to connect via developers support page, and got same – nothing. All these people paid for membership 99 $ and get nothing in results. App store team silent from 1 to 3 month, and then unlock (?) reviewing process without any explanations. Many people with locked apps awaiting response from Apple. Letter written by bot, and you can Google it by key words We appreciate your continued patience during our investigation. If we require any additional information about your app or account, we will contact you. Due to the nature of the investigation you will be ineligible to receive an expedited review until the investigation is completed. Once we have completed our investigation, we will notify you via Resolution Center of any next steps. We are investigating your apps, account, and any related accounts to ensure compliance with the App Store Review Guidelines, Developer Code of Conduct, and Apple Developer Program License Agreement. ![]() However, your account is still under investigation and no action has been taken against it at this time. We understand your concern regarding this investigation. We do not require any additional information from you at this time, nor do we have any additional details to share. Once we have completed our investigation, we will notify you via Resolution Center. We are unable to continue this app’s review because your Apple Developer Program account is currently under investigation for not following the App Store Review Guidelines’ Developer Code of Conductĭuring our investigation, we will not review any apps you submit. Case historyĥ0 days ago I received this message in AppStore Connect: This message written after 50 days awaiting approving my iOS app – FSNotes Manager. One motivation point for me was AppStore sales, and this is now ruined by Apple. I write code almost every day and this is really hard work.įSNotes available for free in brew and GitHub. Over 2 year I am develop FSNotes app, over 1000 commits pushed. Night mode by location or screen brightness.įSNotes is written in Swift 5 and is open source (MIT license).Pinned notes kept in sync with the desktop app.TextBundle and EncryptedTextBundle containers.External editor support (changes seamless live sync with UI).Syntax highlighting within code blocks.Also supports any plaintext and RTF files. Quickly and easily use mouseless note manager on MacĪlthough it has a lot of features in the early stages of development, it still needs some additions, such as a method to quickly sort the list of notes by timestamp, and a method to quickly switch between horizontal and vertical views.Įverything that FSNotes considers is a lightweight and user-friendly note manager designed to increase productivity by helping you create and edit plain or rich text notes without using a mouse.FSNotes is modern notes manager for macOS and iOS. If you need a detailed list of all the functions and keyboard shortcuts available for managing notes, you can find them on the homepage of FSNotes. This allows you to create plain text annotations and highly complex annotations that contain anything from bold text to hyperlinks and images. If you don’t have time for this process, you can also check the notes by opening the notes with the help of an external text editor selected in the application options.įSNotes also has a built-in text formatting function, and supports RTF and Markdown markup languages. Use RTF or Markdown markup to create rich text annotations The only solution we found was to uninstall FSNotes and select the note database folder to restore our notes. Unfortunately, in our tests, we observed that when switching to the horizontal layout, FSNotes appears picky when allowing you to view the content of the note, and the editing area completely disappears. The user interface of FSNotes has vertical and horizontal layouts, both of which consist of an editing area, a search field at the top, and a note list panel to quickly browse notes. More precisely, each FSNotes function has additional predefined keyboard shortcuts, and this fact makes it one of the fastest ways to manage a large number of notes with a Mac. Manage plain text and rich text annotations without the need for a mouse
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![]() These are games that seem identical to the arcade experience. Thanks for your help maintaining this list! If it's already in the Mixed Reviews list and you confirm one of the previous reviews, move it to that list.If the game is in a different category than you have it, move it to the Mixed Reviews list and indicate next to it the two conflicting experiences.If a game is already in the list and in the same category as you would put it, make it bold by adding triple single quotes on either side of the name to indicate confirmation by a second tester.Make sure a game doesn't already exist in a different category.Add games alphabetically and in the appropriate category./media/mmc1/roms (a roms directory on your microSD card)./home/user/MyDocs/roms (This is roms in N900 when mounted via USB mass storage).ROMS go into any of the following folders: Doing the footwork for this kind of thing will greatly help out because the maintainer has neither the time nor the inclination to do this for all ROMs.Īvailable tools are the settings in MAME and the settings in Accelemymote, which controls the accelerometer input as joystick events. For example, portrait mode via rotation (in the settings, push the volume control) is available for games that orient that way, but special consideration of controls are required. Also, you can help out a lot by designing keymaps and other settings for your favorite ROMs and sharing them. See the Talk thread for discussion of the progress. There's no ETA on a completed version due to the huge scope of the project. For example, it might occasionally lock up your phone. At this point, MAME is only available in Extras-devel, due to its incomplete state. For MAME for earlier Maemo versions, see XMAME. Even if this is nothing compared to a real cabinet.The SDL variant of mainline, modern MAME is currently being ported to Maemo 5. Over all, it’s great to play some of the old games again. Or maybe implement two gamepads with one controller. For that I am still unsure, if I should switch to the USB-HID keyboard class. I am planning to have a two player version (Gauntlet!). And the circuit should be more permanent and not that place consuming. The next version should have a more sturdy enclosure. The plastic box works but is way too wobbly. At the moment I am using the “Game Pad” device class. This descriptor is used to tell the PC, what kind of device is attached to the USB port and what kind of data it sends. The biggest problem was to find a matching USB HID report descriptor. ![]() The second was made to play emulated SNES games with a SNES pad. The first one is used to build a simple keyboard. Two projects, that I played with are the HIDKeys example and the SNES-Joypad. The firmware is based on the examples provided at the V-USB page. Therefor the internal pull-up resistors have to be enabled. When I switched to the 12 MHz crystal it worked almost at once.Īll controls, the stick and the buttons, are connected to the controller and to ground. I thought that it should be enough to change the F_CPU setting, but that didn’t work out. ![]() But for prototyping the two diodes will do the job.įirst I tried to run it with a 16 MHz crystal. A better solution would be a low drop 3.3 V voltage regulator. The two 1N4148 diodes reduce the supply from 5 V to about 3.6 V. I used 47 Ohm instead of 68 Ohm for R2 and R3 because I had them laying around. The circuit is almost one of the standard setups, that Obdev recommends. BTW, mine is not Tupperware, but super cheap IKEA. And of course a plastic box as enclosure. A breadboard, an ATmega48 and a couple of resistors, capacitors and diodes. Nothing special about the rest of the needed parts. They are working fine but seem to be a bit too small. I ordered my arcade controls at, a german shop for Arcade parts. The library is licensed under GPL, a commercial license is available as well. It does not require any other chip, only a couple of standard components. This driver can be run on most of all Atmel AVR controllers, even on ATtinys. The next great part is the fantastic USB driver V-USB that is developed by Objective Development. Every device sends a report, in which it states, which kind of device it is and how it wants to report its data. If they behave according to the USB HID spec, then they are automatically recognized by all OSs. The great thing, that this interface brings in, is, the devices don’t need a specific device driver. Common devices of this class are keyboards, mice and joysticks. HID stands for Human Interface Device class. And with a bit of tinkering, you can get a tiny step closer to the real gaming experience. Nothing compares to real arcade controls. One of my best-of-all-times is Bomb Jack.īut you have to play it with the keyboard. If you want to play some retro arcade games, you will install the amazing MAME and run your favorite ROM. ![]() In addition, the unreasonable setting of structural parameters makes the material stress distribution unreasonable, reduces the bearing capacity of the lining structure, and leads to a series of problems such as concrete cracking and excessive deformation of segments ( Guan et al., 2015). At present, there are few water conveyance tunnels with the new composite lining structure of “steel lining-SCC-segment”, and there is a lack of corresponding engineering experience and theoretical research, especially the stress and deformation of each layer lining are still unclear ( Nabipour et al., 2020). Compared with single-layer lining and double-layer lining structures, the new composite lining structure has higher designed internal water pressure, and under the protection of self-compacting concrete lining in the middle layer, the internal steel pipe is not prone to buckling failure ( Gavriilidis and Karamanos, 2019 Yuan and Kyriakides, 2021). Part of the water delivery project with this structure is shown in Figure 1. Facing the construction requirements of large sections, high internal pressure, and complex internal and external loads, part of the project began to try to use the new composite lining structure of “steel lining-self-compacting concrete (SCC)-segment” ( Cao, 2020). Therefore, multi-layer lining structures are usually used in engineering to joint force to improve the overall load-bearing capacity of the structure ( Vogel et al., 2017 Wang et al., 2019 Ding et al., 2020). The water conveyance tunnel structure is not only subjected to external water and soil loads, but also bears large internal water pressure. In order to solve the problem of regional water use, a number of representative shield water conveyance tunnels have been built in China, such as the Pearl River Delta Water Resources Allocation Project ( Yang et al., 2018 Cao, 2020), the Xijiang Water Diversion Project in Guangxi ( Cao, 2020), the South-to-North Water Diversion Project through the Yellow River Tunnel Project ( Chen et al., 2014 Yang et al., 2018a, b) and so on. With the development of regional economy and the difference of population distribution, the problem of water resources distribution is becoming more and more serious. This analysis model and method considering the deformation coordination relationship solves the problem of setting the parameters of the lining structure and has obvious advantages in the calculation of the stress and deformation of the new composite lining water conveyance tunnel structure, which can provide a theoretical basis for related engineering design. In addition, when the thickness of the steel pipe lining is reduced or the internal water pressure is increased, the circumferential stress and radial displacement generated by the inner lining will increase. The larger the elastic modulus of the inner lining material is, the smaller the radial displacement of each lining structure will be, but the circumferential stress of the inner lining will increase. The results show that the radial displacement and circumferential stress of each layer of lining structure decrease with increasing the thickness of the concrete lining. According to the actual project, the rationality of the calculation method is verified by comparing the results of finite element analysis, and the influence of the thickness of intermediate concrete lining and inner lining parameters on the distribution of force transmission among lining layers is further analyzed. ![]() The stress and deformation of each layer of lining are deduced based on the theory of thick-walled cylinders. Each part of the shield assembled lining is regarded as a stressed spring, and a formula for calculating the equivalent elastic modulus of the overall structure at the joint of the lining under partial tension and partial compression is given. ![]() In this paper, the load structure method and the elasticity theory are adopted, the stress analysis model and theoretical calculation method of a new type of composite lining of water conveyance tunnel are given, and the influence law of lining structure parameters is studied. However, there is still no effective analysis model and calculation method for the parameter influence effect of this new composite lining. 2Jiangsu Province Key Laboratory of Soil and Water Conservation and Ecological Restoration, Nanjing, ChinaĪ new type of composite lining structure consisting of segments, steel pipes, and concrete lining can be adopted in the water conveyance tunnel to bear large internal water pressure. ![]() 1School of Civil Engineering, Nanjing Forestry University, Nanjing, China. ![]() 8 last year), Block Blast!, Makeover Studio: Makeup Games, Parking Jam 3D (ranked the same as last year) and Survivor!.io. 2 last year), Gardenscapes, Call of Duty: Mobile (up from No. 3 last year), Royal Match, Subway Surfers (down from No. This list’s No.1 app was MONOPOLY GO!, followed by Roblox (up from No. The top free games, meanwhile, included several of last year’s winners, like Roblox, Call of Duty: Mobile, Subway Surfers and Parking Jam 3D, as well as some new additions. Here, the top 10 included (in order): Shadowrocket, HotSchedules, Procreate Pocket, The Wonder Weeks, 75 Hard, AutoSleep Track Sleep on Watch, Goblin Tools, TonalEnergy Tuner & Metronome, SkyView and AnkiMobile Flashcards. The top paid apps list showcases a different market, more often of smaller developers or those building useful productivity tools, creative apps or utilities that users are willing to pay for. The only other top app in the list not from Meta, Google or a Chinese firm was Max (formerly HBO Max), which showed up as the No. It’s also a heavily-marketed app, just as TikTok was in the months leading up to its No. While Temu attracts users with in-app games, its real draw may be its bargain prices - which have more of an appeal during an economic downturn. Younger users spent even higher amounts of time, at 19 minutes per day, on average. Data from Apptopia, reported by Bloomberg, noted that consumers were spending 18 minutes per day in Temu’s app, compared with 10 minutes in Amazon. consumers haven’t sworn off Chinese apps by the looks of things, given Temu’s No. The negative attention TikTok has received in the year may account for its slip from being the No. Montana also attempted to ban TikTok in its state, but that ruling was put on hold by the courts for the time being as TikTok’s lawsuit progresses. It also points to the growing demand for apps from Chinese firms, like ByteDance, which are attracting younger users’ attention along with government scrutiny, with TikTok being banned from a number of government devices over concerns about its China ties. tech giants are nearly at a market saturation point, where their apps aren’t as in demand as they were in previous years because many already have them installed. The shift in downloads could represent that U.S. ![]() 8 YouTube, both also slipping in ranking from last year. In 2023, however, Google’s only two apps in the top 10 by downloads included No. 2 app YouTube, just behind TikTok, as well as No. Google, meanwhile, had dominated last year’s list with the No. 9, slipping in position from their ranking last year. Gone from the charts is Facebook, while Meta’s new app Instagram Threads was the No. 9 spots with WhatsApp, Instagram and Facebook, respectively, showed up in the top 10 this year with a slightly different mix. ![]() tech giants like Meta and Google, as CapCut and TikTok, which hail from Beijing-based ByteDance, came in at No. This year, apps from Chinese-based companies have taken over spots previously held by U.S. The Cupertino-based tech giant today released an App Store feature that showcases the top iPhone apps of the year, free and paid, as measured by app installs - its proxy for overall popularity. Temu, the Chinese e-commerce company whose app is now attracting longer engagement times than Amazon, is Apple’s most downloaded free app in the U.S. The security features available for Oncourse student login include two-factor authentication, password complexity requirements, and session timeouts. What security features are available for Oncourse student login? Additionally, students can contact their campus Help Desk for assistance. The Knowledge Base provides step-by-step instructions and troubleshooting tips for logging into Oncourse. Use by Yum system franchisees, licensees, suppliers and agencies, and their. Note: Your username has three letters followed by 8 numbers. Login now to get access to MyTacoBell for restaurant and corporate employees. Support for Oncourse student login issues is available through the Indiana University Knowledge Base. When you get to the OnCourse Connect Login Screen - enter your username and your new password into the Guardian side fields. What support is available for Oncourse student login issues? To access your Oncourse student account, you will need to log in to the Oncourse website using your student ID and password. How do I access my Oncourse student account? Then follow the instructions to reset your password. ![]() To reset your Oncourse student login password, go to the Oncourse login page and click the “Forgot Password” link. How do I reset my Oncourse student login password? The Oncourse student login username is typically the student’s school email address. What is the Oncourse student login username? Official Login Link Common Questions What is the URL for Oncourse student login? Official Login Link Customer Login | OCL Financial Services LLC – OnCourse Learning Official Login Link OnCourse Parent Portal – Mount Holly Township School District Post student messages to the OnCourse Connect portal, or send e-mails that include recent grades or progress reports. OnCourse Parent and Student Portal Access – For help accessing or using OnCourse please email us at Login Link OnCourse Connect – Apps on Google Play Official Login Link OnCourse Connect – South Hunterdon Regional School District Parents/Guardians can log into OnCourse Connect by visiting … Connect parent/guardian and/or student login credentials, please contact the Main Office at. ![]() Official Login Link ONCOURSE CONNECT PARENT/GUARDIAN USER GUIDE – Hainesport Township School District English teachers can access the most up-to-date info on … It’s a great online tool for any educator who supports students in their plans after high school. Official Login Link Texas OnCourse Academy OnCourse Connect is a secure web based portal that allows parents, guardians and students to view student information in real time, including: student schedules. All rights reserved | Terms Of Use | Contact Us. Forgot your password? © 2023 OnCourse Systems For Education. ![]() Official Login Link Login – OnCourse Systems For Education Official Login Link Texas OnCourse WebsiteĪccess free and trustworthy resources on college and career planning from Texas OnCourse, a state-funded initiative for educators, students, and families. The OnCourse Connect app provides convenient mobile access to the OnCourse Connect student portal on your phone or tablet. Official Login Link OnCourse Connect on the App Store No information is available for this page. ![]() This is the feature that allows cross-device keyboard and mouse operation between a Mac and an iPad, allowing you to use both input devices on both systems without any initial set-up. For instance, you won't see Universal Control in the first developer beta of macOS Monterey. There are also other forums where developers have listed issues that they've come across. You can see that list here in the macOS Monterey 12 Beta Release Notes. Some Things to Know When Running macOS Monterey Developer BetaĪpple has already listed several known issues in the first beta version of the new OS. Follow the instructions on-screen until you reach the macOS Monterey desktop screen.Ĭongratulations, you are now an Apple developer testing the latest macOS Monterey! Click the button and click on Continue to proceed with the installation. ![]() In the Installer window, when you click Continue, you'll trigger the Software Update window, where you should be able to see an Upgrade Now button. Apple has released a list of devices macOS Monterey 12 supports: Is Your Device Supported by macOS Monterey?Įven before you get a developer account from Apple, you should check if your device is eligible for an upgrade to the new OS version. Make sure you know how to do that and download the installer for that version on a DVD or USB drive beforehand. In this case, that might be macOS Big Sur or an older one like Catalina or Mojave. The only way to retrieve your data would be to do a factory reset or attempt to roll back to an older, stable version of the OS. The reason is obvious but, in case you're new to the beta scenario, you should be aware that beta versions are notoriously buggy and could compromise your entire system. There a rule of thumb before downloading and installing any beta version of an operating system: NEVER do it on your primary device - the one you use for work and other important purposes. Things You Need to Do before Download macOS Monterey Do Not Use Your Primary Device Part 3: The Best UI/UX Design Tool for macOS Monterey.Part 2: How to Download and Install macOS Monterey Beta.Part 1: 4 Things to do before Download macOS Monterey. ![]() However, if you're new to the game, there are several things you should know before you install macOS Monterey beta on your device. If you're a developer or even if you have an Apple Developer account, you can get the installation package. MacOS Monterey, the latest desktop operating system from Apple, is now in its first developer beta. ![]() You can record a button sequence with the Macros tool and then play it back at any time. The recorded video can be used for a variety of different projects, including social media clips, highlight reels, and longer videos uploaded to YouTube.Ĭomplicated combo attacks can be played with a single keypress, which is a huge time saver. Simply switching on Eco Mode can cut your system’s CPU and GPU usage by up to 87% and 97%, respectively.įeel the need to impress your friends with your gaming prowess? Thanks to BlueStacks’ recording feature, you can capture every crucial moment of your game without missing a beat. Use BlueStacks without as much concern for lag or FPS drops on computers with older hardware. With a high frame rate, you’ll have an easier time spotting enemies in action sequences. ![]() Smoother-looking gameplay is achieved with higher FPS because it prevents stuttering and tearing. These days, even the most basic video games come packed with state-of-the-art visuals. Download BlueStacks today and see why millions of people are ditching smartphone gaming for good.īy enabling high frames per second in BlueStacks, you can play your favorite android shooting games in glorious 4K on your PC. Give your kids the freedom to chat and express themselves in a safe and controlled environment with Messenger Kids – The Messaging app made for kids, controlled by parents.ĭownload Messenger Kids – The Messaging on PC with BlueStacks and let your children use messaging apps safely.īlueStacks is an app player that provides its wide user base with over 2 million Android games and apps on PC. Parents can set usage limits for bedtime, and there are no in-app purchases or ads to worry about. Sleep tight knowing that Messenger Kids is worry-free. They can be creative with their conversations using stickers, GIFs, emojis, and even drawing tools! Your kids will have a blast with the fun filters, reactions, and sound effects during video chats. And the best part? No phone number is required, making it easy to start using the app right away. With Messenger Kids, you as a parent can be in control of who your child chats with through a convenient Parent Dashboard. BlueStacks app player is the best platform to run this Android app on your PC or Mac for an immersive gaming experience.Īre you tired of worrying about the content your kids are exposed to on messaging apps? Want to give them a space to chat with friends and family in a safe and controlled environment? Introducing Messenger Kids – The Messaging app made just for kids and controlled by parents! Messenger Kids – The Messaging is a Communication app developed by Meta Platforms, Inc. ![]() Keep in mind that not every Office 2021 package. Essential updates are already integrated. It also wont matter if you use Windows or MacOS, because the packages are suitable for both operating systems. If you want to buy a key for Office 2019 Mac, on the other hand, you only pay a one-time amount and the access to the software remains. Find low everyday prices and buy online for delivery or in-store pick-up. However, you should carefully consider to what extent the regular subscription payments are worth it – more on this in our overview Office 365 vs Office 2019. Shop Microsoft Office Home & Student 2019 (1 Device) Digital Mac OS, Windows Digital at Best Buy. Beyond that, there is only the upgrade to Office 365 left, which is also offered for macOS. In whatever setting you use your Apple product, Microsoft has you covered. The basics mentioned above, from Word to OneNote, are available in all editions, while Office 2019 Home & Business Mac is also considered a license for businesses. Microsoft Office 2019 for Mac, iPad or iPhoneįind the version that suits you best. Thus, Office 2019 Mac performs much better in a direct comparison to Office 2016. In addition, Outlook and OneNote are still included to round out the scope. Office 2019 offers all of this in all versions for both Mac and Windows. Commercial and consumer customers can now purchase Microsoft Office 2019 for Windows and Mac. Finally want to integrate 3D models and pictograms into your Word documents? Get access to advanced charts and formulas in Excel so you can then publish them to Power BI for analysis? Or simply design new transitions for your presentations in PowerPoint to go along with updated drawing features. Whether you buy Microsoft Office Home and Student 2019 Mac or Office 2019 Standard for Mac, the content of the programs always adapts to the needs of the users. ![]() Never warmed up to Microsoft Office’s mirroring technology on Windows? Download Office Mac 2019 and you’ll be able to work right away with the familiar traffic light icons for minimize, maximize, and close – which are, of course, on the left margin. Rather, users can expect a full integration that builds on the experience of Office 2016 for Mac and means an unprecedented collaboration between the two tech giants. This is in no way inferior to the standard version for Windows 10 computers. Because the Mac series is also one of the most popular laptop brands in many countries, both privately and professionally, Office 2019 got its own version for macOS at release. Each order is delivered immediately after purchase, in case of issues or doubt, with free. Payments are secure and tracked with a full money-back warranty. Buy Microsoft Office for Mac suites from Mr Key Shop at competitive prices, with Genuine and guaranteed Digital Licenses. Buy Office 2019 Mac – Microsoft Tools for Catalina & Big Surįor years, Microsoft Office has enjoyed great popularity among users of Apple devices. It includes the 2019 versions of Word, Excel, PowerPoint and OneNote and Outlook, plus youll also receive 60 days of Microsoft support. Office 2019 Home & Business for MAC - Product Key. ![]() ![]() The comprehensive Premium Edition is the best-value option. you don't own Farming Simulator 22 or the variety of packs and expansions. Manufacturers Dewulf, Gorenc, Agrio & WIFO debut in the series, with even more machines by BEDNAR, Fiat, GRIMME, Kverneland, SaMASZ & others. Find out more about the process to sow & harvest carrots, parsnips, and red beet in our Farming Simulator Academy Tutorials! That includes ridge formers to shape ridges before sowing the new crops. More than 35 new vehicles and tools are included: Authentically digitized with more details than ever, the implements extend the fleet to care for new as well as existing crops. There are also new factories, and production chains (soup factory, preserved food factory & potato processing plant) as well as a construction project that needs you to deliver wooden planks for the fancy production of pianos! The picturesque landscape around a remote village offers fertile soil to cultivate the new vegetable crops: carrots, parsnips & red beet - which are added to the list of overall 20 crops. ![]() Zielonka expresses the flair of Germany’s neighbors, drawing inspiration from countries like Poland and the Czech Republic. All in all, you get hundreds of machines from more than 150 brands to operate. Included are the Antonio Carraro Pack, Kubota Pack, Vermeer Pack, Göweil Pack, Hay & Forage Pack, Horsch AgroVation Pack & Oxbo Pack.įurthermore, it contains the Premium Expansion (also available separately) and the forestry-focused Platinum Expansion that introduced Volvo to the series and featured many other brands, gameplay mechanics, a new map, and more. The Premium Edition is a comprehensive package full of content: it includes Farming Simulator 22, six maps, seven official content packs, and both expansions of Year 1 & Year 2. A premium-amount of new content marks the best time to start farming or return to the fields with more machines, maps, and crops than ever: The Premium Expansion and Premium Edition of Farming Simulator 22 are now available on PC & consoles! Here's the Launch Trailer:Įdition: One Game, Two Expansions, Seven Packs ![]() This change can cause cells to clump together, leading to clots and blockages in the blood vessels, starving tissues of oxygen. In patients with sickle cell disease, red blood cells, which are usually disk-shaped, take on a crescent or sickle shape. “It’s been eagerly awaited by patients and families, but also by providers and physicians.” How Casgevy works “It’s something families have been aware of in the early research stage, and they’ve been very patiently waiting for years,” Ferdjallah said. “This could be an equalizer for people with sickle cell because many patients cannot pursue career options” because of the illness. Rabi Hanna, a pediatric hematologist-oncologist at the Cleveland Clinic who has previously served on the advisory board for Vertex. “We really have to make sure that it is accessible,” said Dr. What’s more, that price doesn’t include the cost of care associated with the treatment, like a stay in the hospital or chemotherapy. The pricing strategy, experts argue, may place it out of reach for many families. Still, the new therapy is extremely expensive - $2.2 million per patient, Vertex said. “To really reimagine and re-discuss sickle cell disease as a curable disease and not as this painful and debilitating chronic disease is hope enough with this news.” Asmaa Ferdjallah, a pediatric hematologist and bone marrow transplant physician at the Mayo Clinic in Rochester, Minnesota. “The patient is their own donor,” Thompson said. Using CRISPR, it edits the DNA found in a patient’s stem cells to remove the gene that causes the disease. Until now, the only known cure for sickle cell disease was a bone marrow transplant from a donor, which carries the risk of rejection by the immune system, in addition to the difficult process of finding a matching donor.Ĭasgevy, which was approved for people ages 12 and older, removes the need for a donor. Both treatments work by genetically modifying a patient’s own stem cells. The FDA on Friday also approved a second treatment for sickle cell disease, called Lyfgenia, a gene therapy from drugmaker Bluebird Bio. The approval marks the first of two potential breakthroughs for the inherited blood disorder. “It’s been really remarkable how quickly we went from the actual discovery of CRISPR, the awarding of a Nobel Prize, and now actually seeing it being an approved product.” Alexis Thompson, chief of the division of hematology at Children’s Hospital of Philadelphia, who has previously consulted for Vertex. “I think this is a pivotal moment in the field,” said Dr. |
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